Thus, it is possible that the higher the BMI, the higher the aromatase expression and, consequently, the higher the estrogen production, which could impact the production of progesterone.(32) In addition, obesity and higher BMI, with a higher degree of adiposity, can affect the pharmacokinetic and pharmacodynamic processes of hormones. Here, CYP19A1 is linked to obesity due to melanocortin 4 receptor deficiency.