To assess whether treatment with riboflavin promoted an anti-inflammatory action, with a consequent reduction in the damage generated by the dysregulated response of the immune system during sepsis, we performed the quantification of the pro-inflammatory cytokines IL-6 and TNF-α and the chemokines KC and MIP-2 in serum and peritoneal lavage fluid of septic mice. This evidence concerns the gene IL6 and Sepsis.