Comorbidities such as cirrhosis (OR 8.95 (4.0–15.99)) [45], other liver diseases (adjusted OR 7.78 (3.43–17.64)) [66], or having low CD4 counts (OR 0.96 (0.94–0.99) for a CD4 increase of 10 counts) [77] increased the odds of having HEV. The gene discussed is CD4; the disease is Cirrhosis.