Susceptible individuals with SSc have the unifying abnormal intra-renal features of vasculopathy, fibrosis, and autoimmunity which allow injury to the vessel wall to initiate an amplification loop of local damage and activation of the renin-aldosterone-angiotensin (RAA) axis and hence SRC, as demonstrated by Fig. 2 [17]. Here, SRC is linked to systemic sclerosis.