BACE1 and early-onset autosomal dominant Alzheimer disease: These results are parallel to that of Bhatt et al. (2018) and Chen et al. (2018) who reported that treating rats suffering from Alzheimer’s disease (AD) with nano-nutraceuticals containing NK ameliorated the impaired cognitive functions and enhanced the clearance of Aβ along with the inhibition of the BACE-1 activity, thus suggesting a neuroprotective efficacy of NK.