ARCA1, which is inherited in an autosomal recessive pattern [45], is associated with SYNE1 mutations [46] and its main clinical features include adult-onset (17–46 years), gait and limb ataxia, dysarthria, dysmetria, mild oculomotor abnormalities, and cerebellar atrophy [47]. Here, SYNE1 is linked to Cerebellar atrophy.