The overproduction of NF-κB, which resulted in overexpression of these inflammatory mediators, all are greatly responsible for the development of arthritis, and were documented in multiple studies on human and animals (Tak and Firestein 2001; Yamamoto and Gaynor 2001; Hanada and Yoshimura 2002; Fishman et al. 2006; Shen et al. 2013a; Kamel et al. 2018). The gene discussed is NFKB1; the disease is Arthritis.