Consistent with this pathophysiological cascade we found—among other systemic changes—increasingly abnormal distributions of eGFR and haemoglobin values, higher leukocyte counts and serum CRP levels, and a > 20-fold rise in the percentage of CKD + /A + patients across the ACC/AHA stages, which highlights the syndromal character of the disease [2, 4, 5]. This evidence concerns the gene CRP and chronic kidney disease.