CYP3A5 and obesity due to melanocortin 4 receptor deficiency: An analysis of 4βOHC concentrations based on genotype did not indicate elevated 4βOHC in the individuals expressing CYP3A5 *1/*3 compared with CYP3A5 *3/*3 expressors, neither in normal to overweight individuals (p = 0.95) nor in patients with obesity (p = 0.33) (Supplementary Fig. 6a and b).