Interestingly, in a comparative study of critically ill COVID-19 and influenza A patients, among the immunological factors observed only in those with COVID-19 were increased concentrations of MMP-1 and -3, indicating a possible role of these MMPs in tissue damage associated with severe SARS-CoV-2 infection (Choreño-Parra and others 2021). The gene discussed is MMP1; the disease is COVID-19.