These experiments, together with recent reports that LRG1 is involved in tumor growth, tumor metastasis and emphysema (Hisata et al., 2021 ▸; Singhal et al., 2021 ▸; O’Connor et al., 2021 ▸), indicate that LRG1 affects vascular stability and may be a suitable therapeutic target in multiple pathologies associated with aberrant vascularization and vascular destabilization. The gene discussed is LRG1; the disease is pulmonary emphysema.