Liver FXR-SHP pathway was weakly related to the richness of Dubosiella, Alistipes, and Helicobacter, while NASH favored taxa Mucispirillum and the top 5 most depleted taxa exhibited strong relations with ileum FXR-FGF15-FGFR4 pathway (Fig. S4). The gene discussed is NR0B2; the disease is metabolic dysfunction-associated steatohepatitis.