The PD-L1-targeting D-peptide (NYSKPTDRQYHF, pep) [[20], [21], [22], [23]] on the micelle surface could bind the tumor cell surface PD-L1 via multivalent crosslinking, directing PD-L1 into lysosome degradation and thus downregulating the PD-L1 expression. Here, CD274 is linked to neoplasm.