During pregnancy and in postpartum period, haemodynamic changes, the hypercoagulablestate, hypertensive disorders of pregnancy and their complications contribute to theincreased risk of stroke, on the other hand, acute treatment of stroke is associatedwith the risk of bleeding.7,8 Regarding stroke in pregnant women, a higher stroke risk and higher casefatality was observed.69 Not much is known about the toxicity and long-term effects of recombinanttissue plasminogen (rtPA) for the mother and foetus. This evidence concerns the gene PLG and Stroke.