CXCR4 and medullary thyroid gland carcinoma: Some complementary binding sites between miR-455-5p and CXCL12 have been found, and a significant inverse correlation has been detected as well, indicating that miR-455-5p might suppress medullary thyroid cancer growth and metastasis by targeting CXCL12/CXCR4 signaling pathway [40].