CYP2C19 and obesity due to melanocortin 4 receptor deficiency: Factors of Figure 2 include salicylic acid hydrolyzed from aspirin, P2RY12 inhibiting drugs, CYP2C19 alleles that affect clopidogrel activation, certain comorbidities (DM, obesity, renal failure, and hypertension), medications (proton-pump inhibitor and statins).