KCNH2 and familial long QT syndrome: More recently, in a genetically elusive multigenerational LQTS pedigree, a frameshift variant (p.S1112Pfs*171) in patient-specific hiPSC-CMs was identified as a novel LQT2-causative variant to induce prolonged FPD, a result compared to CRISPR/Cas9-corrected isogenic control hiPSC-CMs (16).