After adjustment for the potential confounders, including sex and the above-mentioned significant indicators, MAFLD (AOR = 2.483, 95% CI 1.412–4.365), age (AOR = 1.114, 95% CI 1.083–1.145), active smoking (AOR = 1.847, 95% CI 1.023–3.335), DAS28-CRP (AOR = 1.168, 95% CI 1.007–1.356), hypertension (AOR = 2.789, 95% CI 1.711–4.546), LDL-C (AOR = 1.791, 95% CI 1.309–2.451), and FLI (AOR = 1.018, 95% CI 1.003–1.033, all p < 0.05, Figure 2B) were the associated factors with high estimated 10-year CVD risk in patients with RA. This evidence concerns the gene CRP and hypertensive disorder.