Apart from these two types of FINs, other methods or compounds can also induce ferroptosis (Figure 1): L-buthionine sulfoximine (BSO) suppresses glutamate-cycteine ligase (GCL) and induces GSH depletion (Seiler et al., 2008; Sun et al., 2018), driving cells to ferroptosis; Cystine starvation leads to glutamate accumulation, GSH biosynthesis reduction, and GPX4 translation blockage, therefore sensitizing cancer cells to ferroptosis (Zhang Y. et al., 2021). This evidence concerns the gene GPX4 and cancer.