In addition, endothelial progenitor cell-derived exosomes seem to ameliorate lung injury in sepsis through miR-126’s post-transcriptional regulation of key targets, such as Sprouty-related protein with an EVH1 domain (SPRED-1), high mobility group box 1 (HMGB1), and vascular cell adhesion molecule 1 (VCAM1) (Wu et al., 2018; Zhou et al., 2018; Zhou et al., 2019). This evidence concerns the gene HMGB1 and Sepsis.