LY96 interacted with TLR4 and activated the nuclear factor-κB (NF-κB) pathway, and thereby promoted the production of pro-inflammatory cytokines and adhesive molecules in colon cancer cells, which accelerate colon cancer growth and lung metastasis (Rajamanickam et al., 2020). This evidence concerns the gene NFKB1 and malignant colon neoplasm.