A variety of stimulating operations in tumor resection can lead to the over-activation of the hypothalamic-pituitary-adrenal axis (HPA) and abnormal excitation of the sympathetic center, which in turn causes related reactions of catecholamines, massive release of stress-related neurotransmitters such as serum Cor and ET, and inflammatory factors such as TNF-α and IL-6. The gene discussed is TNF; the disease is neoplasm.