As the critical role of classical PTEN, a member-permeable protein, PTEN-Long can act on the PI3K-AKT-mTOR pathway and enter neighboring cells following its secretion from cells, dephosphorylating PIP3, antagonizing PI3K-AKT signaling and inducing cell death in renal cell carcinoma (18). The gene discussed is AKT1; the disease is renal cell carcinoma.