The recognized risk factors for RA-associated BR are: RF and/or ACPA serum positivity, the presence of HLA-DRB1*0401 or DQB1*0601, DQB1*0301, DQB1*0201, DQA1*0501 haplotypes, and cystic fibrosis transmembrane conductance regulator mutations (68). Here, PRTN3 is linked to rheumatoid arthritis.