HSC-1 and HSC-5 cells have also been used to look at the expression of IGF2BP3 (Insulin Like Growth Factor 2 mRNA Binding Protein 3) as a biomarker to distinguish between cSCC and keratoacanthoma (79) or to evaluate the role of CXCR7 expression in cSCC (80). The gene discussed is ACKR3; the disease is skin squamous cell carcinoma.