ALT (OR = 1.060, P < 0.0001; 1.047, P = 0.001; 1.052, P < 0.0001), AST (OR = 1.153, P < 0.0001; 1.138, P < 0.0001; 1.142, P < 0.0001), ALB (OR = 1.468, P < 0.0001; 1.400, P < 0.0001; 1.397, P < 0.0001), Dbil (OR = 4.274, P < 0.0001; 2.939, P < 0.0001; 2.528, P < 0.0001) and sTim-3 (OR = 1.332, P < 0.0001; 1.416, P < 0.0001; 1.386, P < 0.0001) were independent risk factors for hepatitis or liver fibrosis after HBV, HCV, and HEV infection, respectively. The gene discussed is ALB; the disease is hepatitis A virus infection.