The results of the qRT-PCR analysis confirmed further increases in the renal fibrosis markers vimentin and FSP-1 in the SAMP1-50wk mice, and that the expression of the glomerulosclerosis marker podocin was decreased in the SAMP1-20wk mice, SAMP1-30wk mice, 40-wk mice, and SAMP1-50wk mice (Figure 6D). The gene discussed is S100A4; the disease is glomerulosclerosis.