Histologically, compared to the SAMP1-30wk mice and the SAMP1-30wk+control-miRNA-PEI-NP mice, the SAMP1-30wk+miRNA-503-5p-inhibitor-PEI-NP mice showed no improvement of glomerulosclerosis (Figure 7C). Here, TMEM201 is linked to glomerulosclerosis.