The qRT-PCR analysis confirmed further increases in the renal fibrosis markers FSP-1 and vimentin in the SAMP1-50wk mice (Figures 1C,D), and that the expression of the glomerulosclerosis marker podocin was decreased in the SAMP1-50wk mice (Figure 2C). The gene discussed is S100A4; the disease is glomerulosclerosis.