Besides, NOX4 could increase hypoxia-induced IL-6 and IL-8 production in RCC, linking NOX4 to inflammation-induced RCC metastasis and making NOX4 a therapeutic target to reduce IL-6- and IL-8-induced inflammation and invasion in RCC (Fitzgerald et al., 2012). The gene discussed is CXCL8; the disease is renal cell adenocarcinoma.