AKT1 and neoplasm: ROS could regulate a variety of signaling pathways, including PI3K/AKT, hypoxia-inducible factor-1α (HIF-1α), c-myc, NF-κB, and STAT3, and other molecules, thus linking to growth, metastasis, angiogenesis and chemoresistance of tumor (Zhang et al., 2014; Prasad et al., 2017).