Neoplasia has been found in the liver and pancreas of various autophagy-deficient mouse models, including Becn1 heterozygous mice (Qu et al., 2003; Yue et al., 2003), systemic mosaic Atg5 deletion mice (Takamura et al., 2011), and liver- or pancreas-specific Atg5 or Atg7 deletion mice (Inami et al., 2011; Takamura et al., 2011; Rosenfeldt et al., 2013; Yang et al., 2014). Here, ATG5 is linked to neoplasm.