BECN1 and Other metabolic disease: Furthermore, many single nucleotide polymorphisms (SNPs) on ATG genes have been identified to associate with the onset of metabolic diseases by genome-wide association studies, for example, rs10512488 in Becn1 (Tamargo-Gómez et al., 2020), but their potential functions and mechanisms in the regulation of autophagy activity and energy metabolism are still unknown.