Similar to the process described for other tumor types, a vicious cycle exists when myeloma cells home to the marrow and release cytokines and factors that induce osteoclast activity and bone destruction, including TNF-α, IL-1, IL-3, and IL-6 (Figures 3B, 4) (Edwards et al., 2008; Kawano et al., 1988; Lee et al., 2004). The gene discussed is IL6; the disease is neoplasm.