We and others have shown ALS-linked mutations impair TDP-43 mobility in axons (Alami et al., 2014; Gopal et al., 2017) and dendrites (Liu-Yesucevitz et al., 2014) and reduce net anterograde transport of Nefl mRNA in the axon (Alami et al., 2014). Here, TARDBP is linked to amyotrophic lateral sclerosis.