TARDBP and amyotrophic lateral sclerosis: The importance of the RGG and single tyrosine (Y374) on TDP-43 RNP transport is not known, but the existence of several ALS-associated mutations in the vicinity of R293 and a nonsense mutation (Y374X) that produces a truncated form of TDP-43 (TDP-43 1–373) raise the possibility of a functional role (Buratti, 2015).