TARDBP and amyotrophic lateral sclerosis: Nearly all (97%) ALS cases show pathologic aggregation and nuclear depletion of TDP-43 (transactive response DNA-binding protein of 43 kDa), a highly conserved, ubiquitously expressed DNA/RNA-binding protein which regulates post-transcriptional RNA processing and mRNA stability, translation, and transport (Neumann et al., 2006; Ling et al., 2013; Taylor et al., 2016).