We and others have shown ALS-linked mutations impair TDP-43 mobility in axons (Alami et al., 2014; Gopal et al., 2017) and dendrites (Liu-Yesucevitz et al., 2014) and reduce net anterograde transport of Nefl mRNA in the axon (Alami et al., 2014). The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.