TARDBP and amyotrophic lateral sclerosis: In addition, we disrupted the only RGG found in the LCD of TDP-43 (R293 K/A), since there are five ALS-linked mutations associated with this motif (G294V, G294A, G295S, G295R, and G295C), highlighting the importance of this motif in TDP-43 biology (Phan et al., 2011).