Inactivation of USP35 in a zebrafish model of BBS4 ciliopathy, rescues different ciliary defects, such as impaired convergent and extension movements during gastrulation, renal tubule convolution and retinal degeneration, thus ameliorating the phenotype(s) of BBS4-depleted animals (Tsai et al., 2019). The gene discussed is BBS4; the disease is ciliopathy.