Inhibition of miR-208a reduces MI-induced fibrosis, while injection of miR-208a-containing EVs into post-MI rat hearts increases fibrosis, most likely by targeting mRNA encoding Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Dyrk2), an inhibitor of nuclear factor of activated T-cells (NFAT)-mediated myofibroblast differentiation (Yang et al., 2018). This evidence concerns the gene DYRK2 and myocardial infarction.