Inhibition of miR-150-5p, which is enriched in EVs from cultured hypoxic tubular cells and targets suppressor of cytokine signaling 1 (SOCS1), reduces fibroblast activation, fibronectin expression, and fibrosis in vivo, demonstrating that hypoxic tubular cells secrete EVs that aggravate renal fibrosis (Zhou et al., 2021). Here, FN1 is linked to renal fibrosis.