SOCS1 and renal fibrosis: Inhibition of miR-150-5p, which is enriched in EVs from cultured hypoxic tubular cells and targets suppressor of cytokine signaling 1 (SOCS1), reduces fibroblast activation, fibronectin expression, and fibrosis in vivo, demonstrating that hypoxic tubular cells secrete EVs that aggravate renal fibrosis (Zhou et al., 2021).