Chang et al. (2015) demonstrated that increased glucose consumption inhibits T cell metabolism by lowering glycolytic capacity, mTOR activity, and IFNγproduction. Evidence suggests that glucose deprivation restrains T cell’s anti-tumor effects (Cascone et al., 2018), and the competition in the TME interferes with antigen-specific responses of tumor-infiltrating T cells. Here, MTOR is linked to neoplasm.