Evidence has shown that LUCAT1 could participate in proliferation, migration and invasion of esophageal squamous cell carcinoma (Yoon et al., 2018), ovarian cancer (Yu et al., 2018), prostate cancer (Liu et al., 2020), et al. Nevertheless, whether LUCAT1 influences metastasis and glycolysis in LUAD, and if yes, what is the regulatory mechanism, remains to be further explored. The gene discussed is LUCAT1; the disease is esophageal squamous cell carcinoma.