SIRT3 and medical procedure: For example, luteolin (MOL000006) is an unique component in MH, has properties of anti-inflammatory, neuroprotective, anti-allergic, and vascular protection (Qiu et al., 2013; Pandurangan and Esa, 2014; Su et al., 2021), and has been proved to enhance mitochondrial function by increasing the transduction of Sirtuin 3 (SIRT3) through the SIRT3/AMPK/mTOR pathway and to reduce the infarcted area of middle cerebral artery occlusion (MCAO) rat model (Liu S. et al., 2020).