MAP2K7 and ischemic disease: The reports have shown that Ras and MEK can play actions in Ras/Raf/MEK/ERK signaling pathways and can be regulated by some miRNAs such as miRNA-21 and miRNA-26a, which can induce angiogenesis to aid in blood vessel formation for vascular tissue engineering in ischemic diseases (Ding M.-H.