Additionally, according to published reports, these genes are widely enriched in the pathways that are closely associated with stroke, such as Cytokine-cytokine receptor interaction (hsa04060) (IL6, TNF), PI3K-Akt signaling pathway (hsa04151) (IL6, NOS3, VEGFA), MAPK signaling pathway (hsa04010) (TNF, VEGFA), and Ras signaling pathway (hsa04014) (VEGFA). This evidence concerns the gene PIK3CD and stroke disorder.