INS and type 2 diabetes mellitus: For example, Pan et al. used the network pharmacology model and experimental validation to confirm that quercetin in Huanglian Decoction (HLD) affected the synthesis of glucose transporter 4 (GLUT4) by interfering with the insulin signaling pathway and improved the therapeutic effect of HLD on type 2 diabetes (T2DM) (Pan et al., 2020).