The reports showed that the VEGF signaling pathway could affect the protein activity of VEGF, mediate in angiogenesis and blood supply (Wu et al., 2019), reduce the formation of brain edema in the poststroke (Peng et al., 2014; Hu et al., 2019), and could promote dendrite and synaptic plasticity and improve nerve recovery in stroke (Shim and Madsen, 2018; Xie et al., 2019). Here, VEGFA is linked to stroke disorder.