IL5RA and chronic obstructive pulmonary disease: This process is clinically common in allergic diseases, asthma, chronic obstructive pulmonary diseases (COPD), etc., Meanwhile, cytokine receptors such as IL-5R are also expressed in the sensory nerve endings, receiving cytokine signals in the inflammatory response, producing positive feedback and enhancing immunity (Huh and Veiga-Fernandes, 2020).