Sensory nerves from the dorsal root ganglion can not only release neuromedin U (NMU) to promote the proliferation of ILC2 and type 2 inflammatory response (Cardoso et al., 2017; Klose et al., 2017; Wallrapp et al., 2017), but also secrete neuromedin B (NMB) to inhibit ILC2 response, eosinophilia, and mucus production in the stage of allergic inflammation and worm infection, forming a bidirectional regulation (Chen et al., 2020b; Inclan-Rico et al., 2020). This evidence concerns the gene NMB and helminthiasis.