In general, circ-ABCB10 can act as an oncogene by promoting tumor proliferation and migration in glioma, non–small cell lung cancer, esophageal cancer, breast cancer, and renal cancer (Tang et al., 2017; Deng et al., 2018; Wang et al., 2018; Wang et al., 2020; Zhao et al., 2020) and can also be an anti-oncogene by inhibiting the growth in hepatocellular carcinoma and cervical cancer (Gao et al., 2017a; Feng et al., 2021). The gene discussed is ABCB10; the disease is esophageal cancer.