In glioblastoma, the C-terminal cytoplasmic tail of Vangl serves as a scaffold for Nrdp1 to mediate K63-polyubiquitination of Dvl, which prevents the recruitment of Dvl to membrane localized Fzd, suppressing downstream signaling and cell motility (Wald et al., 2017). The gene discussed is DVL1; the disease is glioblastoma.