One study observed that Vangl1 complexes with the polarity protein Scrib and the adaptor protein NOS1AP at the leading edge of lamellipodia, suggesting that the assembly of Vangl1-Scrib-NOS1AP complexes at the leading-edge of migratory breast cancer cells may promote engagement of downstream signaling components critical to breast cancer cell polarity and motility (Anastas et al., 2012). This evidence concerns the gene VANGL1 and breast cancer.