SCRIB and breast cancer: One study observed that Vangl1 complexes with the polarity protein Scrib and the adaptor protein NOS1AP at the leading edge of lamellipodia, suggesting that the assembly of Vangl1-Scrib-NOS1AP complexes at the leading-edge of migratory breast cancer cells may promote engagement of downstream signaling components critical to breast cancer cell polarity and motility (Anastas et al., 2012).