Although PIPKIα, mutant p53 and sHSPs are independently implicated in tumor progression (Arrigo and Gibert, 2014; Muller et al., 2014; Semenas et al., 2014; Malin et al., 2016), findings indicate that these proteins form an orchestrated molecular complex that may play a central role in tumorigenesis. The gene discussed is TP53; the disease is neoplasm.