The strong and widespread distribution of Agr2+/Aqp5+/DBA− ductal cells in the IPMN TMA were further confirmed by Hscore, as Agr2 and Aqp5 staining were much higher than the DBA-FITC staining (Figure 6B). Here, AGR2 is linked to pancreatic intraductal papillary-mucinous neoplasm.