To determine if this was relevant to human IPMN, we performed Agr2/DBA-FITC IF staining as well as Aqp5 and GSK-3β IHC staining on serial sections from a tissue microarray (TMA) containing 140 human IPMN cases (see patient demographics of TMA in Supplementary Table S6) (Whitcomb et al., 2012). The gene discussed is AGR2; the disease is pancreatic intraductal papillary-mucinous neoplasm.