PDX1 and familial pancreatic carcinoma: To examine the impact of GSK-3β ablation on pancreatic cancer progression, the pancreas was collected from 8- to 10-month-old Pdx1-cre (Wildtype, WT), Pdx1-cre/GSK-3βF/F (KO), Pdx1-cre/LSL-KRasG12D (KC) and Pdx1-cre/LSL-KRasG12D/GSK-3βF/F (RKO) littermates (Supplementary Figure S1A, upper panel).