AQP5 and neoplasm: Consistent with the role of Aqp5 as a source for early tumor formation in gastric cancer (Tan et al., 2020) and pancreas injury-associated pancreatic precursor initiation (Ma et al., 2022), Aqp5+ progenitor-like ductal cells from KNGC mice are indeed more proliferative and deletion of Aqp5 in KNGC animals results in more acinar cell development and less ductal formation.