ETP-ALL blasts showed enrichment in Toll like receptor (TLR) cascades and pro-inflammatory cytokine (Interleukin-1, Interleukin-17, Interferon-γ) signalling pathways (Figure 2F, Supplementary Table S3), likely to be mediated by inflammatory protein complexes containing Transforming Growth Factor (TGF)-β, Phospholipase C-γ etc (Figure 2G, Supplementary Table S4). The gene discussed is IL17A; the disease is acute lymphoblastic leukemia.