For example, inhibition of either spastizin/SPG15 or spatacsin/SPG11, the two major genes associated with hereditary spastic paraplegia (HSP), results in accumulation of autolysosomes and depletion of free lysosomes, indicating their critical role in ALR (Chang et al., 2014). This evidence concerns the gene ZFYVE26 and hereditary spastic paraplegia.