Cioccoloni et al. (2020) found that the overexpressed FASN was associated with the increased PD-L1 expression in a human T-cell leukemia line, and blocking the FASN by Orlistat impaired the expression of the PD-L1. PD-L1 with highly palmitoylation was observed in cisplatin-resistant BC bladder cancer cells (Shahid et al., 2020). The expression and palmitoylation of FASN could increase PD-1 expression and palmitoylation (Shahid et al., 2020). This evidence concerns the gene CD274 and breast cancer.