NANOG, which mediated oncogenic pathways including stimulating fatty acid oxidation (FAO) and suppressed oxidative phosphorylation (OXPHOS) through mitochondrial metabolic reprogramming, inhibited chemotherapy-induced apoptosis by suppressing ROS production to promote chemoresistance of tumor-initiating stem-like cells (TICs) (Chen et al., 2016). Here, NANOG is linked to neoplasm.