In addition to EGFR mutated cancer cells, Akt pathway was related to chemoresistance in FASN-overexpressed gastrointestinal stromal tumors (GISTs) with KIT mutated and the activation of oncogenic pathway like PI3K/AKT/mTOR pathway promoted chemoresistance to imatinib (Li et al., 2017). Here, AKT1 is linked to gastrointestinal stromal tumor.