Two lipid metabolism-associated enzymes, lysophosphatidylcholine acyltransferase 3 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) participate in the formation of membrane phospholipids from PUFAs such as arachidonic acid (AA) or adrenic acid (AdA), thus protecting cancer cells against ferroptosis (Chen et al., 2021; Lee et al., 2021). Here, LPCAT3 is linked to cancer.