CCL4 and melanoma: Wnt signaling was also correlated with immune exclusion in melanoma by reducing the secretion of CCL4, a chemokine that attracts the immune cells (Spranger et al., 2015; Weppler et al., 2020) It was also involved in melanoma progression by regulating cell proliferation and invasion and promoting resistance to targeted therapies (Xue et al., 2016).