The results showed that the expression level of C8orf49, LINC01588, LINC02489, C9orf147, and AC126773.3 were significantly up-regulated in ESCC samples compared with normal control samples, while TMEM161B-AS1 was down-regulated in ESCC samples (Figure 11A). This evidence concerns the gene PTGDR and esophageal squamous cell carcinoma.