TG and hypothyroidism: In rats, previous studies have reported that hypothyroidism decreases plasma levels of gonadotropins and reduces the number and size of gonadotrophs (Bruni et al., 1975; Ruiz et al., 1988), suggesting that the absence of thyroid hormones is associated with gonadal dysfunctions (Amin and El-Sheikh, 1977; Hernandez, 2018).