HIF1A and hydrops fetalis: Additionally, HF patients with EF <45% are included in clinical regeneration studies as a need for cardiac regeneration MSC-HF (Mathiasen et al., 2020), or on-going SCIENCE (Paitazoglou et al., 2019)); accordingly, the animals in the pMSC-MiCi-HIF-1α have reached a level of therapeutic efficacy.