In addition, several studies demonstrated that the antagonists or inhibitors of ANGPTL4, follistatin, HGF, uPAR, and VEGF receptors aggravate the renal damage in AKI animal models (Eddy, 2002; Zhang et al., 2003a; Ma and Fogo, 2009; Zhou D. et al., 2013; Chugh et al., 2014; Clement et al., 2014; Fang et al., 2016; Leonhard et al., 2016; Estrada et al., 2019; Fujii et al., 2019; An et al., 2020; Mohan and Herrmann, 2022). This evidence concerns the gene ANGPTL4 and acute kidney injury.