INS and type 2 diabetes mellitus: In this regards, the Earth-based paradigm of patients with T2DM, with important microvascular complications and relevant wound repair impairment, may suggest at least in part what are the consequences of marked/prolonged insulin resistance on the complex process of wound healing (Fu et al., 2021; Rodríguez-Rodríguez et al., 2022), and suggest some potential experimental approaches to begin to disentangle this pathophysiological problem.